Levosimendan for Septic Myocardial Dysfunction
نویسندگان
چکیده
منابع مشابه
Myocardial dysfunction in pediatric septic shock.
OBJECTIVE To evaluate the prevalence and significance of myocardial dysfunction in children with septic shock. STUDY DESIGN Thirty patients with septic shock were evaluated by transthoracic echocardiography within 24 hours of admission to a pediatric critical care unit. Transthoracic echocardiography evaluation included left ventricular (LV) size and function, mitral valve inflow velocities i...
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B a mmHg; the patient developed tachycardia of 130 beats/minute and became hemodynamically unstable despite volume resuscitation. Urgent laparotomy was performed because of clinical and radiological signs of ileus. Surgical abdominal exploration showed closed-loop obstruction due to adhesions with necrosis of the ileum. Resection of the ileum with terminal ilio-ascending colon anastomosis was p...
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Introduction: Levosimendan, a calcium sensitizer and opener of ATP-dependent potassium channels, has positive inotropic, vasodilatory, and cardioprotective properties. Method: 28 patients with acute myocardial infarction and/or cardiogenic shock (50%) scheduled for emergency surgical revascularization were treated with levosimendan in addition to catecholamines. Results: 21 (75%) patients survi...
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BACKGROUND We aimed to investigate the effect of levosimendan on biomarkers of myocardial injury and systemic hemodynamics in patients with septic shock. MATERIAL AND METHODS After achieving normovolemia and a mean arterial pressure of at least 65 mmHg, 38 septic shock patients with low cardiac output (left ventricular ejective fraction), LEVF £45%) were randomly divided into two groups: levosi...
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INTRODUCTION Mechanisms underlying inotropic failure in septic shock are incompletely understood. We previously identified the presence of exosomes in the plasma of septic shock patients. These exosomes are released mainly by platelets, produce superoxide, and induce apoptosis in vascular cells by a redox-dependent pathway. We hypothesized that circulating platelet-derived exosomes could contri...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2015
ISSN: 0090-3493
DOI: 10.1097/ccm.0000000000001328